Medical Reference Library

At Stem Solutions, we strictly adhere to a robust code of ethics and comply with all regenerative medicine laws and regulations set by Cofepris. We are committed to transparency and have compiled an extensive list of medical studies related to the conditions we treat. This resource will be updated regularly to ensure you have access to the latest information.

Mesenchymal stem cell for the treatment of neurodegenerative disease. Regen Med. 2010, November, 5(6)933-946. Doi:10.2217/rme.10.72 Helena Vilaça-Faria, António J. Salgado and Fábio G. Teixeira

Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson’s disease. Cells2019, 8(2), 118; doi:3390/cells8020118 Teixeira, F.G.; Carvalho, M.M.; Neves-Carvalho, A.; Panchalingam, K.M.; Behie, L.A.; Pinto, L.; Sousa, N.; Salgado, A.J.

Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation. Stem Cell Rev.2015, 11, 288–297. [Google Scholar] [CrossRef] [PubMed]

Gao, F.; Chiu, S.M.; Motan, D.A.; Zhang, Z.; Chen, L.; Ji, H.L.; Tse, H.F.; Fu, Q.L.; Lian, Q.

Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis.2016, 7, e2062. [Google Scholar] [CrossRef] [PubMed] Joyce, N.; Annett, G.; Wirthlin, L.; Olson, S.; Bauer, G.; Nolta, J.A.

Mesenchymal stem cells for the treatment of neurodegenerative disease. Med.2010, 5, 933–946. [Google Scholar] [CrossRef] [PubMed] Fraga, J.S.; Silva, N.A.; Lourenco, A.S.; Goncalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; Manadas, B.; Sousa, N.; Salgado, A.J.

Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations. Biochimie2013, 95, 2297–2303. [Google Scholar] [CrossRef] [PubMed]Ribeiro, C.A.; Fraga, J.S.; Graos, M.; Neves, N.M.; Reis, R.L.; Gimble, J.M.; Sousa, N.; Salgado, A.J.

The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations. Stem Cell Res. Ther.2012, 3, 18. [Google Scholar] [CrossRef]

Ribeiro, C.A.; Salgado, A.J.; Fraga, J.S.; Silva, N.A.; Reis, R.L.; Sousa, N.

The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures). Tissue Eng. Regen. Med.2011, 5, 668–672. [Google Scholar] [CrossRef]

Salgado, A.J.; Fraga, J.S.; Mesquita, A.R.; Neves, N.M.; Reis, R.L.; Sousa, N.

Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF. Rep.2017, 7, 4153. [Google Scholar] [CrossRef] Serra, S.C.; Costa, J.C.; Assuncao-Silva, R.C.; Teixeira, F.G.; Silva, N.A.; Anjo, S.I.; Manadas, B.; Gimble, J.M.; Behie, L.A.; Salgado, A.J.

Influence of passage number on the impact of the secretome of adipose tissue stem cells on neural survival, neurodifferentiation and axonal growth. Biochimie2018, 155, 119–128. [Google Scholar] [CrossRef]

Assuncao-Silva, R.C.; Mendes-Pinheiro, B.; Patricio, P.; Behie, L.A.; Teixeira, F.G.; Pinto, L.; Salgado, A.J.

Exploiting the impact of the secretome of MSCs isolated from different tissue sources on neuronal differentiation and axonal growth. Biochimie2018, 155, 83–91. [Google Scholar] [CrossRef] [PubMed]

Cai J, Wu J, Wang J, Li Y, Hu X, Luo S et al.

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential. Cell & Bioscience. 2020;10(1):1-14. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al.

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-317. Ding D, Chang Y, Shyu W, Lin S.

Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy. Cell Transplantation. 2015;24(3):339-347. Mishra V, Shih H, Parveen F, Lenzen D, Ito E, Chan T et al.

Identifying the Therapeutic Significance of Mesenchymal Stem Cells. Cells. 2020;9(5):1145. Regmi S, Pathak S, Kim J, Yong C, Jeong J.

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives. European Journal of Cell Biology. 2019;98(5-8):151041. Piittenger MF, Discher DE, Peault BM, et al.

Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019; 4: 22.

Yen B, Yen M, Wang L, Liu K, Sytwu H.

Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID ‐19. STEM CELLS Translational Medicine. 2020;9(10):1163-1173.

Srivastava A. Diabetes: stem cells offering healthy promises. Journal of Stem Cell Research & Therapeutics. 2018;4(2).

Riordan N, Hincapié M, Morales I, Fernández G, Allen N, Leu C et al.

Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels. STEM CELLS Translational Medicine. 2019;8(10):1008-1016.

Siniscalco D, Kannan S, Semprún-Hernández N, Eshraghi A, Brigida A, Antonucci N.

Stem cell therapy in autism: recent insights. Stem Cells and Cloning: Advances and Applications. 2018;Volume 11:55-67.

Srivastava A.

Inflammatory Bowel Diseases: Current Therapeutic Approaches and Potential of Using Stem Cells. Journal of Stem Cell Research & Therapeutics. 2017;2(2). S Srivastava A.

Cardiovascular Diseases: Recent Developments in Regenerative Medicine. Journal of Stem Cell Research & Therapeutics. 2017;. Alessio N, Brigida A, Peluso G, Antonucci N, Galderisi U, Siniscalco D.

Stem Cell-Derived Exosomes in Autism Spectrum Disorder. International Journal of Environmental Research and Public Health. 2020;17(3):944. El Omar R, Beroud J, Stoltz J, Menu P, Velot E, Decot V.

Umbilical Cord Mesenchymal Stem Cells: The New Gold Standard for Mesenchymal Stem Cell-Based Therapies?. Tissue Engineering Part B: Reviews. 2014;20(5):523-544. Chute, J.P. Stem cell homing. Curr Opin Hematol 13, 399,2006

Nekanti, U., Rao, V.B., Bahirvani, A.G., Jan, M., Totey, S., and Ta, M.

Long-term expansion and pluripotent marker array analysis of Wharton’s jelly-derived mesenchymal stem cells. Stem Cells Dev 19, 117, 2010. De Miguel, M. P.; Fuentes-Julian, S.; Blazquez-Martinez, A.; Pascual, C. Y.; Aller, M. A.; Arias, J.; Arnalich-Montiel, F.

Immuno-suppressive properties of mesenchymal stem cells: Advances and applications. Curr. Mol. Med. 12(5):574–591; 2012. Arrigoni C, D’Arrigo D, Rossella V, Candrian C, Albertini V, Moretti M

Arthritis

Umbilical Cord MSCs and Their Secretome in the Therapy of Arthritic Diseases: A Research and Industrial Perspective. Cells. 2020;9(6):1343. El-Jawhari J, El-Sherbiny Y, McGonagle D, Jones E.

Multipotent Mesenchymal Stromal Cells in Rheumatoid Arthritis and Systemic Lupus Erythematosus; From a Leading Role in Pathogenesis to Potential Therapeutic Saviors?. Frontiers in Immunology. 2021;12. El-Jawhari JJ, El-Sherbiny YM, Jones EA, McGonagle D.

Mesenchymal stem cells, autoimmunity and rheumatoid arthritis. QJM. (2014) 107:505–14. 10.1093/qjmed/hcu033

Luque-Campos N, Contreras-López R, Jose Paredes-Martínez M, Torres M, Bahraoui S, Wei M et al.

Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response. Frontiers in Immunology. 2019;10. Lopez-Santalla M, Fernandez-Perez R, Garin M.

Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications. Cells. 2020;9(8):1852. Yang C, Wu M, You M, Chen Y, Luo M, Chen Q.

Autoimmune disorders

The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases. Stem Cell Research & Therapy. 2021;12(1). Lu M, DiBernardo E, Parks E, Fox H, Zheng S, Wayne E.

The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders. Frontiers in Immunology. 2021;12. Baharlooi H, Azimi M, Salehi Z, Izad M.

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases. International Journal of Stem Cells. 2020;13(1):13-23. El-Jawhari J, El-Sherbiny Y, McGonagle D, Jones E.

Mesenchymal stem cells, autoimmunity and rheumatoid arthritis. QJM. (2014) 107:505–14. 10.1093/qjmed/hcu033

Gao F, Chiu SM, Motan DA, Zhang Z, Chen L, Ji HL, et al. . Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis. (2016) 7:e2062. 10.1038/cddis.2015.327 Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H et al.

Long term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocrine Journal. 2013;60(3):347-357. Gugliandolo A, Bramanti P, Mazzon E.

Mesenchymal Stem Cells in Multiple Sclerosis: Recent Evidence from Pre-Clinical to Clinical Studies. International Journal of Molecular Sciences. 2020;21(22):8662. Leyendecker Jr. A, Pinheiro C, Amano M, Bueno D.

The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for the in vivo Treatment of Immune-Related Diseases: A Systematic Review. Frontiers in Immunology. 2018;9. Regmi S, Pathak S, Kim J, Yong C, Jeong J

Inflammation

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives. European Journal of Cell Biology. 2019;98(5-8):151041.

Srivastava A.

Inflammatory Bowel Diseases: Current Therapeutic Approaches and Potential of Using Stem Cells. Journal of Stem Cell Research & Therapeutics. 2017;2(2). De Miguel, M. P.; Fuentes-Julian, S.; Blazquez-Martinez, A.; Pascual, C. Y.; Aller, M. A.; Arias, J.; Arnalich-Montiel, F.

Immuno-suppressive properties of mesenchymal stem cells: Advances and applications. Curr. Mol. Med. 12(5):574–591; 2012. Castro-Manrreza, M. E., & Montesinos, J. J. (2015).

Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. Journal of immunology research, 2015, 394917. https://doi.org/10.1155/2015/394917 Ryu, J. S., Jeong, E. J., Kim, J. Y., Park, S. J., Ju, W. S., Kim, C. H., Kim, J. S., & Choo, Y. K. (2020).

Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases. International journal of molecular sciences, 21(21), 8366. https://doi.org/10.3390/ijms21218366 Srivastava A.

Diabetes

Diabetes: stem cells offering healthy promises. Journal of Stem Cell Research & Therapeutics. 2018;4(2).

Solis, M. A., Moreno Velásquez, I., Correa, R., & Huang, L. (2019). Stem cells as a potential therapy for diabetes mellitus: a call-to-action in Latin America. Diabetology & metabolic syndrome, 11, 20. https://doi.org/10.1186/s13098-019-0415-0 Kamal, M. M., & Kassem, D. H. (2020).

Therapeutic Potential of Wharton’s Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges. Frontiers in cell and developmental biology, 8, 16. https://doi.org/10.3389/fcell.2020.00016 Moreira, A., Kahlenberg, S., & Hornsby, P. (2017).

Therapeutic potential of mesenchymal stem cells for diabetes. Journal of molecular endocrinology, 59(3), R109–R120. https://doi.org/10.1530/JME-17-0117 Scuteri, A., & Monfrini, M. (2018).

Mesenchymal Stem Cells as New Therapeutic Approach for Diabetes and Pancreatic Disorders. International journal of molecular sciences, 19(9), 2783. https://doi.org/10.3390/ijms19092783 Abdul Wahid, S. F., Law, Z. K., Ismail, N. A., & Lai, N. M. (2019)

Motor Neuron Disease

Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease. The Cochrane database of systematic reviews, 12(12), CD011742. https://doi.org/10.1002/14651858.CD011742.pub3 Lewis, C. M., & Suzuki, M. (2014).

Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis. Stem cell research & therapy, 5(2), 32. https://doi.org/10.1186/scrt421 Gugliandolo, A., Bramanti, P., & Mazzon, E. (2019).

Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?. Stem cells international, 2019, 3675627. https://doi.org/10.1155/2019/3675627 Angeloni, C., Gatti, M., Prata, C., Hrelia, S., & Maraldi, T. (2020).

Role of Mesenchymal Stem Cells in Counteracting Oxidative Stress-Related Neurodegeneration. International journal of molecular sciences, 21(9), 3299. https://doi.org/10.3390/ijms21093299 Karussis, D., Karageorgiou, C., Vaknin-Dembinsky, A., Gowda-Kurkalli, B., Gomori, J. M., Kassis, I., Bulte, J. W., Petrou, P., Ben-Hur, T., Abramsky, O., & Slavin, S. (2010).

Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Archives of neurology, 67(10), 1187–1194. https://doi.org/10.1001/archneurol.2010.248 Wang, Y. H., Wu, D. B., Chen, B., Chen, E. Q., & Tang, H. (2018)

Liver Disease

Progress in mesenchymal stem cell-based therapy for acute liver failure. Stem cell research & therapy, 9(1), 227. https://doi.org/10.1186/s13287-018-0972-4 Monsel, A., Zhu, Y. G., Gennai, S., Hao, Q., Liu, J., & Lee, J. W. (2014).

Cell-based therapy for acute organ injury: preclinical evidence and ongoing clinical trials using mesenchymal stem cells. Anesthesiology, 121(5), 1099–1121. https://doi.org/10.1097/ALN.0000000000000446 de Miguel, M. P., Prieto, I., Moratilla, A., Arias, J., & Aller, M. A. (2019).

Mesenchymal Stem Cells for Liver Regeneration in Liver Failure: From Experimental Models to Clinical Trials. Stem cells international, 2019, 3945672. https://doi.org/10.1155/2019/3945672 Esrefoglu M. (2013).

Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World journal of gastroenterology, 19(40), 6757–6773. https://doi.org/10.3748/wjg.v19.i40.6757 Ma, H. C., Wang, X., Wu, M. N., Zhao, X., Yuan, X. W., & Shi, X. L. (2016).

Interleukin-10 Contributes to Therapeutic Effect of Mesenchymal Stem Cells for Acute Liver Failure via Signal Transducer and Activator of Transcription 3 Signaling Pathway. Chinese medical journal, 129(8), 967–975. https://doi.org/10.4103/0366-6999.179794 Mansoor H, Ong H, Riau A, Stanzel T, Mehta J, Yam G.

Eye Disease

Current Trends and Future Perspective of Mesenchymal Stem Cells and Exosomes in Corneal Diseases. International Journal of Molecular Sciences. 2019;20(12):2853. Adak S, Magdalene D, Deshmukh S, Das D, Jaganathan B. A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases. Stem Cell Reviews and Reports. 2021;.

Ding SLS, Kumar S, Mok PL (2017)

Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases. International Journal of Molecular Sciences 18. 10.3390/ijms18081406 Gater R (2016)

Development of Better Treatments for Retinal Disease Using Stem Cell Therapies. International Journal of Stem cell Research & Therapy. 10.23937/2469-570x/1410032 Ramsden CM, Powner MB, Carr A-JF, Smart MJK, da Cruz L, Coffey PJ (2013)

Stem cells in retinal regeneration: past, present and future. Development (Cambridge, England). 10.1242/dev.092270

Fu et al. Stem cell transplantation therapy in Parkinson’s disease. SpringerPlus (2015) 4:597 Joyce et al

Degenerative disease

Mesenchymal stem cell for the treatment of neurodegenerative disease. Regen Med. 2010, November, 5(6)933-946. Doi:10.2217/rme.10.72 Helena Vilaça-Faria, António J. Salgado and Fábio G. Teixeira

Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation. Stem Cell Rev.2015, 11, 288–297. Joyce, N.; Annett, G.; Wirthlin, L.; Olson, S.; Bauer, G.; Nolta, J.A.

Mesenchymal stem cells for the treatment of neurodegenerative disease. Med.2010, 5, 933–946 Fraga, J.S.; Silva, N.A.; Lourenco, A.S.; Goncalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; Manadas, B.; Sousa, N.; Salgado, A.J.

Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations. Biochimie2013, 95, 2297–2303. Salgado, A.J.; Fraga, J.S.; Mesquita, A.R.; Neves, N.M.; Reis, R.L.; Sousa, N.

Role of human umbilical cord mesenchymal progenitors conditioned media in neuronal/glial cell densities, viability, and proliferation. Stem Cells Dev.2010, 19, 1067–1074. Gu, J., Huang, L., Zhang, C., Wang, Y., Zhang, R., Tu, Z., Wang, H., Zhou, X., Xiao, Z., Liu, Z., Hu, X., Ke, Z., Wang, D., & Liu, L. (2020)

Cerebral Palsy

Therapeutic evidence of umbilical cord-derived mesenchymal stem cell transplantation for cerebral palsy: randomized, controlled trial. Stem cell research & therapy, 11(1), 43. https://doi.org/10.1186/s13287-019-1545-x Boruczkowski, D., & Zdolińska-Malinowska, I. (2019).

Wharton’s Jelly Mesenchymal Stem Cell Administration Improves Quality of Life and Self-Sufficiency in Children with Cerebral Palsy: Results from a Retrospective Study. Stem cells international, 2019, 7402151. https://doi.org/10.1155/2019/7402151 Huang, L., Zhang, C., Gu, J., Wu, W., Shen, Z., Zhou, X., & Lu, H. (2018).

A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy. Cell transplantation, 27(2), 325–334. https://doi.org/10.1177/0963689717729379

Nitkin, C. R., Rajasingh, J., Pisano, C., Besner, G. E., Thébaud, B., & Sampath, V. (2020).

Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatric research, 87(2), 265–276. https://doi.org/10.1038/s41390-019-0425-5 Novak, I., Walker, K., Hunt, R. W., Wallace, E. M., Fahey, M., & Badawi, N. (2016).

Concise Review: Stem Cell Interventions for People With Cerebral Palsy: Systematic Review With Meta-Analysis. Stem cells translational medicine, 5(8), 1014–1025. https://doi.org/10.5966/sctm.2015-0372 Yen B, Yen M, Wang L, Liu K, Sytwu H.

Lung Disease

Current status of mesenchymal stem cell therapy for immune/inflammatory lung disorders: Gleaning insights for possible use in COVID ‐19. STEM CELLS Translational Medicine. 2020;9(10):1163-1173. Enes, S. R., Uriarte, J. J., Pouliot, R. A., & Weiss, D. J. (2019).

Clinical Application of Stem/Stromal Cells in COPD. Stem Cell-Based Therapy for Lung Disease, 97–118. https://doi.org/10.1007/978-3-030-29403-8_6 Behnke, J., Kremer, S., Shahzad, T., Chao, C. M., Böttcher-Friebertshäuser, E., Morty, R. E., Bellusci, S., & Ehrhardt, H. (2020).

MSC Based Therapies-New Perspectives for the Injured Lung. Journal of clinical medicine, 9(3), 682. https://doi.org/10.3390/jcm9030682 Guo, H., Su, Y., & Deng, F. (2021).

Effects of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Future Perspectives. Stem cell reviews and reports, 17(2), 440–458. https://doi.org/10.1007/s12015-020-10085-8

Cho, J. W., Park, K. S., & Bae, J. Y. (2019).

Effects of Wharton’s jelly-derived mesenchymal stem cells on chronic obstructive pulmonary disease. Regenerative therapy, 11, 207–211. https://doi.org/10.1016/j.reth.2019.07.009

Autism

Riordan N, Hincapié M, Morales I, Fernández G, Allen N, Leu C et al. Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels. STEM CELLS Translational Medicine. 2019;8(10):1008-1016. Siniscalco D, Kannan S, Semprún-Hernández N, Eshraghi A, Brigida A, Antonucci N.

Stem cell therapy in autism: recent insights. Stem Cells and Cloning: Advances and Applications. 2018;Volume 11:55-67.

Alessio N, Brigida A, Peluso G, Antonucci N, Galderisi U, Siniscalco D.

Stem Cell-Derived Exosomes in Autism Spectrum Disorder. International Journal of Environmental Research and Public Health. 2020;17(3):944. Liu, Q., Chen, M. X., Sun, L., Wallis, C. U., Zhou, J. S., Ao, L. J., Li, Q., & Sham, P. C. (2019).

Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders. World journal of stem cells, 11(2), 55–72. https://doi.org/10.4252/wjsc.v11.i2.55 Siniscalco, D., Sapone, A., Cirillo, A., Giordano, C., Maione, S., & Antonucci, N. (2012).

Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?. Journal of biomedicine & biotechnology, 2012, 480289. https://doi.org/10.1155/2012/480289 Ichim, T. E., Solano, F., Glenn, E., Morales, F., Smith, L., Zabrecky, G., & Riordan, N. H. (2007).

Stem cell therapy for autism. Journal of translational medicine, 5, 30. https://doi.org/10.1186/1479-5876-5-30

Cai J, Wu J, Wang J, Li Y, Hu X, Luo S et al.

General MSC Studies

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential. Cell & Bioscience. 2020;10(1):1-14. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, et al.

Mesenchymal stem cells in the wharton’s jelly of the human umbilical cord. Stem Cells (2004) 22:1330–7. 10.1634/stemcells.2004-0013 Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al.

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-317. Ding D, Chang Y, Shyu W, Lin S.

Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy. Cell Transplantation. 2015;24(3):339-347. Mishra V, Shih H, Parveen F, Lenzen D, Ito E, Chan T et al. Identifying the Therapeutic Significance of Mesenchymal Stem Cells. Cells. 2020;9(5):1145. Pittenger MF, Discher DE, Peault BM, et al.

Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019; 4: 22.

El Omar R, Beroud J, Stoltz J, Menu P, Velot E, Decot V.

Umbilical Cord Mesenchymal Stem Cells: The New Gold Standard for Mesenchymal Stem Cell-Based Therapies?. Tissue Engineering Part B: Reviews. 2014;20(5):523-544. Nagamura-Inoue T, He H.

Umbilical cord-derived mesenchymal stem cells: their advantages and potential clinical utility. World J Stem Cells. (2014) 6:195–202. 10.4252/wjsc.v6.i2.195 Chute, J.P. Stem cell homing. Curr Opin Hematol 13, 399,2006

Nekanti, U., Rao, V.B., Bahirvani, A.G., Jan, M., Totey, S., and Ta, M.

Long-term expansion and pluripotent marker array analysis of Wharton’s jelly-derived mesenchymal stem cells. Stem Cells Dev 19, 117, 2010. Fan XL, Zhang Y, Li X, Fu QL.

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy. Cell Mol Life Sci. (2020) 77:2771–94. 10.1007/s00018-020-03454-6 Gao, F.; Chiu, S.M.; Motan, D.A.; Zhang, Z.; Chen, L.; Ji, H.L.; Tse, H.F.; Fu, Q.L.; Lian, Q.

Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis.2016, 7, e2062.

Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J.

Mesenchymal stem cells for regenerative medicine. Cells. (2019) 8:886. 10.3390/cells8080886